Nature of cell kinetics in psoriatic epidermis
نویسندگان
چکیده
منابع مشابه
Altered Levels of Sphingosine and Sphinganine in Psoriatic Epidermis
BACKGROUND Ceramides are the main lipid component of the stratum corneum and are a structurally heterogeneous and complex group of sphingolipids of which sphingoid bases are the basic structural constituents. Altered levels of sphingoid bases have been reported in skin conditions that involve dryness and barrier disruption, including atopic dermatitis. OBJECTIVE The purpose of this study was ...
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Ceramides are the main lipids in the stratum corneum and are generated during cellular stress and apoptosis by de novo synthesis or by the action of sphingomyelinase. In addition, they are lipid second messengers produced by sphingolipid metabolism and trigger important cell responses, including protein kinase C-alpha (PKC-alpha) activation and the stimulation of signal transduction pathways wi...
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ژورنال
عنوان ژورنال: Journal of Cutaneous Pathology
سال: 2007
ISSN: 0303-6987,1600-0560
DOI: 10.1111/j.1600-0560.2006.00719.x